Brand Name Manufacturers	Dufaston Duphaston Duvaron Gynorest Terolut Gestotron Prodel Retrone Pregna Isopregnenone Hydrogestrone
Generic Manufacturers	None?
Pharmacology	Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Chemical name: Pregna-4,6-diene-3,20-dione, (9beta,10alpha)-
Delivery	10 mg tablets (US) 5, 10, 20mg tablets (UK)
Typical dosage	Unknown for transsexual HRT in the US. The following were provided by someone in the UK. where Dydrogesterone has been available longer: Pre-op 5-20mg/day Post-op 2.5-10mg/day
Availability	Approved by U.S. FDA
Indications	dysmenorrhoea, endometriosis, amenorrhoea, premenstrual syndrome
Contraindications	long-term liver problem heart or circulatory problems including clotting disorders diabetes
Adverse reactions	Swollen feet/ankles, weight gain, nausea, vomiting, breast tenderness, depression, headache
Comments	An unintentional extra dose is unlikely to be a cause for concern. But if you notice unusual symptoms, or if a large overdose has been taken then notify your doctor.
Additional Info:	Dydrogesterone Official Monograph (PDF file on this site)

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