| Brand
Name Manufacturers |
Menest
by SK Beecham Pharm
Estratab by Solvay |
| Generic
Manufacturers |
Cheshire
|
| Pharmacology
|
Esterified
estrogens are a mixture of the sodium salts of the sulfate
esters of the estrogenic substances, principally estrone.
They seem to act on estrogenic receptors the same as endogenous
estrogen. |
| Delivery
|
Oral
0.3, 0.625, 1.25, 2.5mg tablets |
| Typical
dosage |
Pre-op
2.5-10mg/day
Post-op 0.625-5mg/day |
| Availability
|
Approved
by U.S. FDA |
| Indications
|
Estrogen
replacement therapy in females. Inoperable progressing breast
or prostate cancer. |
| Contraindications
|
Active
blood clotting disorders. Estrogen-dependent tumors. History
of blood clotting disorders associated with estrogen use.
History of sensitivity to estradiol or any part of the preparation.
Known or suspected breast cancer except in appropriately
selected patients. |
| Adverse
reactions |
- CNS
- Dizziness.
Headache. Mental depression. Migraine. Spasms of limb
and facial muscles.
- Eyes
- Intolerance
to contact lenses. Steepening of corneal curvature.
- Gastrointestinal
- Abdominal
cramps. Bloating. Cholestatic jaundice. Nausea. Vomiting.
- Skin
- Blood
eruptions from skin. Blotchy skin pigmentation. Increase
of body and facial hair. Loss of scalp hair. Red skin
patches from capillary congestion.
- Other
- Blood
clotting disorders. Breast and liver tumors. Elevated
blood pressure. Fluid retention. Gall bladder disease.
Increased sensitivity to light. Increased serum calcium
level. Reduced glucose tolerance.
|
| Comments
|
none |
| Additional
Info: |
Menest
Prescribing Information (PDF file on this site) |