| Brand
Name Manufacturers |
Depo-Estradiol
by Pharmacia/Upjohn |
| Generic
Manufacturers |
Depogen
by Hyrex
Dep-gynogen by Forest
Estro-cyp by Keene
Goldline
Moore
Rugby
Steris |
| Pharmacology
|
Ester
with estradiol same effect as endogenous estrogen |
| Delivery
|
Sustained
release intramuscular injection, 5mg/ml |
| Typical
dosage |
Pre-op
1.5-4mg/2wks injection
Post-op 1-3mg/2-4wks injection |
| Availability
|
Approved
by U.S. FDA |
| Indications
|
Estrogen
replacement therapy in females |
| Contraindications
|
Active
blood clotting disorders. Estrogen-dependent tumors. History
of blood clotting disorders associated with estrogen use.
History of sensitivity to estradiol or any part of the preparation.
Known or suspected breast cancer except in appropriately
selected patients. |
| Adverse
reactions |
- CNS
- Convulsions.
Dizziness. Headache. Migraine. Mental depression. Spasms
of limb and facial muscles.
- Eyes
- Intolerance
to contact lenses. Steepening of corneal curvature.
- Gastrointestinal
- Abdominal
cramps. Bloating. Cholestatic jaundice. Nausea. Vomiting.
- Skin
- Blotchy
skin pigmentation. Localized skin irritation. Loss of
scalp hair. Increase of body hair. Red skin patches
from capillary congestion.
- Other
- Blood
clotting disorders. Elevated blood pressure. Fluid retention.
Glucose intolerance. Increased serum calcium level.
Increased sensitivity to light. Liver tumors.
|
| Comments
|
The
1997 pdr generics book shows a 1:10 ratio of cypionate:valerate
ovarian failure replacement dosages. This has been roughly
confirmed in the limited anecdotal evidence gathered from
transsexuals. |
| Additional
Info: |
Depo-Estradiol
Prescribing Information (PDF file on this site) |