Brand
Name Manufacturers |
Almedion
by ?
Aquadiol by ?
Climara by Berlex Labs (film)
Dermestril by ? in Italy
Estraderm by Ciba (film)
Estrace by B/M Squibb (oral)
Estrafem by Novo Nordisk in Denmark
Estrovite by ?
Follicyclin by ?
Gynoestryl by ?
Menorest by ?
Oestrogel by Laboratoires Besins Iscovesco
Ovociclina by ? in Italy
Ovocyclin by ?
Profoliol B by ? in Switzerland
Vagifem by ?
Vivelle by Ciba (film)
Zumenon by Solvay |
Generic
Manufacturers |
Apothecon
Geneva
Goldline
Major
Moore
Qualitest
Rugby
Watson |
Pharmacology
|
17b
estradiol with same effect as endogenous estrogen |
Delivery
|
Oral
tablets 0.5, 1, 2mg
Extended release film 0.0375, 0.05, 0.075, 0.1mg/24hrs
Vaginal cream and suppositories
Gel |
Typical
dosage |
Pre-op
oral 4-8mg/day, 2-4 film patches 0.1 changed twice weekly
Post-op oral 1-4mg/day, film 0.05 or 0.1 changed twice weekly
- weekly
Need more data about typical cream, suppository, and gel
dosage and absorption. |
Availability
|
Approved
by U.S. FDA |
Indications
|
Estrogen
replacement therapy in females |
Contraindications
|
Active
blood clotting disorders. Estrogen-dependent tumors. History
of blood clotting disorders associated with estrogen use.
History of sensitivity to estradiol or any part of the preparation.
Known or suspected breast cancer except in appropriately
selected patients. |
Adverse
reactions |
- CNS
- Convulsions.
Dizziness. Headache. Migraine. Mental depression. Spasms
of limb and facial muscles.
- Eyes
- Intolerance
to contact lenses. Steepening of corneal curvature.
- Gastrointestinal
- Abdominal
cramps. Bloating. Cholestatic jaundice. Nausea. Vomiting.
- Skin
- Blotchy
skin pigmentation. Localized skin irritation. Loss of
scalp hair. Increase of body hair. Red skin patches
from capillary congestion.
- Other
- Blood
clotting disorders. Elevated blood pressure. Fluid retention.
Glucose intolerance. Increased serum calcium level.
Increased sensitivity to light. Liver tumors.
|
Comments
|
The
Climara and Vivelle films reportedly lasts longer, and
probably deliver more, than the Estraderm brand. |
Additional
Info: |
Climara
Patient Insert (PDF file on this site)
Estradiol
Tablets Prescribing Information (PDF file on this
site)
Estraderm
Prescribing Information (PDF file on this site) |