| Brand
Name Manufacturers |
Ogen
by Pharmacia/Upjohn |
| Generic
Manufacturers |
Caremark
Duramed
Goldline
Ortho-est by Ortho Pharm
Qualitest
Rugby
Schein
URL
Warner Chilcott
Watson |
| Pharmacology
|
Sulfate
of estrone, stabilized with piperazine. Apparently acts
on receptors the same as endogenous estrogen. |
| Delivery
|
Oral
0.75, 1.5, 3mg tablets |
| Typical
dosage |
Pre-op
?
Post-op Oral 1.5-9mg/day |
| Availability
|
Approved
by U.S. FDA |
| Indications
|
Estrogen
replacement therapy in females |
| Contraindications
|
Active
blood clotting disorders. Known or suspected breast cancer,
unless that is the target. Known or suspected estrogen dependent
tumors. |
| Adverse
reactions |
- CNS
- Dizziness.
Headache. Mental depression. Migraine. Spasms of limb
and facial muscles.
- Eyes
- Intolerance
to contact lenses. Steepening of corneal curvature.
- Gastrointestinal
- Abdominal
cramps. Bloating. Cholestatic jaundice. Nausea. Vomiting.
- Skin
- Blood
eruptions from skin. Blotchy skin pigmentation. Increase
of body and facial hair. Loss of scalp hair. Red skin
patches from capillary congestion.
- Other
- Blood
clotting disorders. Breast tumors. Elevated blood pressure.
Fluid retention. Gall bladder disease. Increased calcium
level in blood. Increased sensitivity to light. Reduced
carbohydrate tolerance.
|
| Comments
|
Since
estropipate is a quot;natural estrogenic substance prepared
from purified crystalline estrone", the source is likely
to be pregnant mares, the same as for conjugated and esterified
estrogens. Refuting or confirming evidence would be appreciated.
|
| Additional
Info: |
Ogen
Product Insert (PDF file on this site) |