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Gender Identity Disorder Information
 

Flutamide

Brand Name Manufacturers

Eulexin by Schering
Euflex by Schering
Chimax by Waymade (UK)
Drogenil by Schering-Plough (UK)
Eulexin (FLUTAMIDA GADOR ) by Gador/Seignior/Massone

Generic Manufacturers Euflexin by ?
Cytomid by CIPLA
Elbat by Genepharm
Pharmacology Strong androgen receptor antagonist
Delivery 125mg oral capsules
250mg oral capsules
Transdermal, usully 1% Flutamide USP (see note below)
Typical dosage Pre-op 375-750mg/daily in 3 divided doses (see comments below on dosing)
Post-op (not recommended)
Availability Approved by U.S. FDA
Indications Androgen-sensitive prostate cancer
Contraindications Hypersensitivity to any component of the product
Adverse reactions
CNS
Anxiety. Confusion. Depression. Drowsiness. Nervousness.
Gastrointestinal
Anorexia. Diarrhea. Nausea. Vomiting.
Other
Decreased leukocyte blood cell count. Decreased platelet blood cell count. Decreased red blood cell count. Fluid retention. Elevated blood pressure. Hot flashes. Liver disease. Breast tenderness or fullness. Fatigue.
Comments

Not recommended for transsexual HRT regimens. Danger of liver toxic reactions too common, often indicated by drug-induced porphyria. Immediate cessation of flutamide relieves symptoms.

A recent study in Brazil found that lower doses of flutamide were just as effective at fighting unwanted hair growth as higher doses, but posed far less risk of negative side-effects. Doses as low as 62.5mg/day were found to be just as effective as 250mg/day had been. This may be something to take into account for anyone planning to use flutamide as part of their HRT. [ source: Dermatology Times ]

The transdermal form of delivery has no brand name or commercial manufacturer. Some people get a compounding pharmacy to mix flutamide with "Sintov Gel." Most compounding pharmacies will only put 1% flutamide USP in the gel, which may not be enough. Some users of these formulatios suggest that 5% is the most effective amount, but may be hard to have made at that strength.

Additional Info: Eulexin Manufacturer's Data Sheet for Physicians (PDF file on this site)

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