Brand Name Manufacturers	Lupron by Tap
Generic Manufacturers	None company
Pharmacology	GnRH agonist. After an initial stimulating phase, the pituitary is desensitized to GnRH, which causes it to stop producing LH, which in turn dramatically decreases gonadal production of hormones within one month.
Delivery	5, 7.5, 11.25, 15, 22.5mg sustained-release intramuscular injection
Typical dosage	Pre-op 3.75-7.5mg/month
Availability	Approved by U.S. FDA
Indications	Advanced prostate cancer. Endometriosis.
Contraindications	Hypersensitivity to GnRH or GnRH analogs.
Adverse reactions	CNS Anxiety. Delusions. Dizziness. Headache. Hearing disorders. Insomnia. Memory disorder. Nerve disorders. Personality disorder. Eyes Eye disorders. Gastrointestinal Anorexia. Constipation. Coughing up blood. Dry mouth. Nausea. Thirst. Vomiting. Skin Change of facial and body hair. Skin rash. Other Ankylosing spondylosis. Blood in the urine. Bone and muscle pain. Change in heart electrical activity. Congestive heart failure. Decrease of bone density. Decreased tolerance of protein. Decreased red blood cell count. Decreased white blood cell count. Difficulty urinating. Elevated blood pressure. Elevated LDH. Elevated phosphorus. Escape of blood into the tissues from ruptured blood vessels. Fluid retention. Hair loss. Hot flashes. Increased heart beat rate. Increased uric acid. Increased urination frequency or urgency. Lactation. Liver disorder. Loss of strength. Low blood pressure. Lymphadenopathy. Mild to extreme allergic reaction. Palpitations. Pelvic fibrosis. Penile swelling. Prostate pain. Pulmonary disorders. Respiratory disorders. Temporary increase of hormone production. Temporary suspension of respiration and circulation.
Comments	FDA warning about misleading product information (PDF file on this site)
Additional Info	Lupron-Depot Pediatric (lower dose) Prescribing Information (PDF file, this site) Lupron-Depot (full dose) Prescribing Information (PDF file on this site)

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