|
Adverse reactions |
- CNS
-
Headache. Insomnia. Loss of coordination. Mental depression.
Sleepiness. Slurred speech. Weakness, numbness, or pain
in extremeties.
- Eyes
-
Change of vision.
- Gastrointestinal
-
Cholestatic jaundice. Nausea.
- Skin
-
Skin discoloration, rash, itching, and other allergic
reactions.
- Other
-
Blood clotting disorders. Chest pain. Decreased glucose
tolerance. Fever. Fluid retention. Shortness of breath.
|
|
Comments |
There
are many anecdotal reports of inexplicable or exacerbated
depression while taking this drug. In that case, natural
progesterone is indicated.
Upjohn
claims that the bioavailability of Provera is higher than
generic formulations.
The
article "Gender Dysphoria Update" by Blaine R. Beemer (originally
published in Journal of Psychosocial Nursing and Mental
Health Services, 1996: 34(4), 12-19) reports that clients
at Vancouver (BC) "routine receive the progestin medroxyprogesterone
acetate (Provera)" and asserts that apart "from its effect
as an antiandrogen, medroxyprogesterone has been shown to
promote bone formation, and may counter the bone loss that
might occur with the bllockade of male hormones," citing
as a reference: Prior, JC, Vigna, YM, Barr, SI, Rexworthy,
C, & Lentle, BC (1994), "Cyclic medroxyprogesterone treatment
increases bone density: A controlled trial in active women
with menstrual cycle disturbances. American Journal of Medicine,
96, 521-530. A question to consider: does the medroxyprogesterone
administration have to be cyclic to have the bone density
effect? |