|
Brand Name Manufacturers |
Synarel by Searle |
|
Generic Manufacturers |
None |
|
Pharmacology |
GnRH agonist. After an initial stimulating phase, The pituitary
is desensitized to GnRH, which causes it to stop producing
LH, which in turn dramatically decreases gonadal production
of hormones within one month. |
|
Delivery |
Nasal spray |
|
Typical dosage |
Pre-op 1600mcg/day (2 sprays into each nostril twice a day)
|
|
Availability |
Approved by U.S. FDA |
|
Indications |
Central precocious puberty. Endometriosis. |
|
Contraindications |
Hypersensitivity to GnRH, GnRH agonists analogs or any component
of the product |
|
Adverse reactions |
- CNS
-
Headache. Insomnia. Mental depression.
- Skin
-
Acne. Body odor. Increase of body and facial hair. Itchiness.
Itchy, fluid-filled patches of skin. Oily skin. Rash.
Vaginal dryness.
- Other
-
Chest pain. Fluid retention. Hot flashes. Muscle pain.
Nasal irritation. Ovarian cysts. Shortness of breath.
Vaginal bleeding.
|
|
Comments |
None |
| Additional
Info |
Synarel
Prescribing Information (PDF file on this site) |