|
Brand Name Manufacturers |
Aldactone by Searle
Spironolacton by ? in Bulgaria
Uractone by ? in Italy
Verospiron by ? in Hungary |
|
Generic Manufacturers |
Caremark
Cheshire
Geneva
Goldline
Heartland
Major
Moore, H.L.
Mutual
Mylan
Parmed
PD-RX
Purepac
Qualitest
Raway
Rugby
UDL
URL
Vanguard |
|
Pharmacology |
Mostly inhibits production of testosterone at the stage of
17-hydroxylation, and competes with DHT (dihydrotestosterone)
for bonding at peripheral receptors. It is also said to intensify
catabolism of androgens, and activate conversion of testosterone
into estrogens. |
|
Delivery |
25, 50, 100mg oral tablets |
|
Typical dosage |
Pre-op 100-400mg/day
Post-op 50mg/day |
|
Availability |
Approved by U.S. FDA |
|
Indications |
Congestive heart failure. Elevated blood pressure. Fluid retention.
Hyperaldasteronism. Inadequate pottasium retention. Liver
cirrhosis. |
|
Contraindications |
Elevated potassium levels. Inadequate urine production. Kidney
disfunction. |
|
Adverse reactions |
- CNS
-
Confusion. Dizziness. Drowsiness. Headache. Lethargy.
Loss of precise motor control.
- Gastrointestinal
-
Cramping. Diarrhea. Dry mouth. Gastric ulceration and
other stomach inflammation. Vomiting.
- Skin
-
Acne. Itchy, fluid-filled patches of skin. Increase of
body and facial hair. Red skin patches from capillary
congestion.
- Other
-
Deepening of the voice. Drug fever. Pottasium retention.
Severe decrease of blood granulocytes. Sodium loss.
|
|
Comments |
One person reported suicidal depression as an adverse effect.
The brand-name formulation tastes awful; the generic formulation
is much less offensive. |
| Additional
Info: |
Aldactone
Product Insert (PDF file on this site) |